t 



90 Scientific Proceedings (28). 



intervals of about two minutes, produces only in some cases an 

 increase in the blood sugar. 



3. Ligation of all branches of the hepatic artery running to 

 the liver produces no change in the sugar content of the blood. 



4. Stimulation of the tissues adjacent to the portal vein — after 

 doubly ligating and cutting — causes hyperglycemia in about 

 fifty per cent, of the cases. Such stimulation does not usually 

 cause any change in arterial blood pressure. 



As a result of these four groups of experiments it would 

 appear that local asphyxia of the hepatic lobule consequent upon 

 changes in blood supply is a less likely explanation of hyper- 

 glycogenolysis than is the hypothesis which assumes the presence 

 of glycogenolytic secretory fibers in the great splanchnic nerves. 



If such fibers control the production of glycogenolytic ferment 

 by the liver, we might expect atropin to paralyze the fibers. My 

 observations in this direction, however, show that stimulation of 

 the N. splanchnicus in atropinized dogs causes the usual hyper- 

 glycemia. Atropin itself, however, produces a hyperglycemia 

 which makes the observation of doubtful value. 



Experiments are in progress to determine by the method of 

 Bang, Lyungdahl and Bohm 1 whether there is an increased 

 amount of glycogenolytic ferment in the liver after stimulation of 

 the great splanchnic nerve. 



52 (308) 



Prevention of syphilis in Macacus Rhesus by atoxyl. 

 By SIMON FLEXNER. 



\From the Rockefeller Institute for Medical Research.'] 



The drug atoxyl has been employed successfully in causing 

 the rapid disappearance of syphilitic lesions in human beings and 

 in preventing the development of the specific inoculation eye 

 lesions in rabbits. Metchnikoff reported recently that the same 

 drug would prevent the development of the specific lesion in 

 monkeys even if administered some days after the inoculation. 



1 Beitrage zur chemischen Physiologie und Pathologie, 1907, ix, p. 408 ; x, p. I ; 

 x, p. 312. 



