112 



Scientific Proceedings (29). 



vomiting, lasting twenty four to forty eight hours. The case was 

 reported by us to the Association of American Physicians, May 

 12. A study of the urinary nitrogen was made November 6 to 

 December 2, '07, and April 7 to May 5, '08, embracing three at- 

 tacks during the first period and two during the second. Urea 

 and ammonia nitrogen did not vary beyond normal limits. The 

 chief interest centered in the uric acid and creatinin output. Dur- 

 ing the latter part of the first period the uric acid, on a uniform purin- 

 free diet of 2,350 calories for a girl of 47.3 kilos, showed a dis- 

 tinct fall before the last attack, with a subsequent rise. During the 

 second period the patient was kept on a creatin and purin-free diet 

 unrestricted as to quantity, the amounts of creatinin and uric acid 

 rising sharply after each attack, the latter showing a fall before the 

 attack. Throughout the whole period the uric acid showed as wide 

 variations as Kaufman and Mohr, and von Noorden and Schliep, 

 described in the subjects of true gout. A test of her tolerance for 

 exogenous purins, however, showed that her elimination of uric 

 acid after eating 580 grams of beef was even higher than Burian 

 and Schur's normal figure of 50 per cent. The creatinin was also 

 wholly eliminated. Comparison of the eliminations during these 

 two days with those in the urine after the attacks shows that, in the 

 latter urines, she excreted as much additional uric acid and creat- 

 inin as might be derived from 580 grams of beef, with a nitrogen 

 loss of 10 grams after the first attack and 13 grams after the 

 second. The increased nitrogen output on the two meat days 

 over the previous average was about 9 grams. The increase in 

 the uric acid and creatinin, therefore, would seem to correspond 

 closely with the amount of toxic tissue destruction that occurred in 

 these short paroxysms of fever. 



68 (324) 



Histological changes in transplanted blood vessels. 

 By WILBUR WARD. 



Communicated by Francis Carter Wood. 



[From the Department of Clinical Pathology of Columbia Univer- 

 sity, at the College of Physicians and Surgeons .] 

 It has been shown by many experimenters that segments of 

 blood vessels may be transplanted to other vessels, in animals 



