Scientific Proceedings. ( 20 5) 35 



duced into the common bile duct and the rate of secretion studied 

 by comparing the quantities collected for periods of 15 minutes 

 each. In one experiment in which secretion proved to be very 

 scanty, the bile was collected for an hour and the quantity obtained 

 during that period was compared with the amounts collected for 

 equal lengths of time after injection of alcohol. Various strengths ot 

 alcohol were used : 25 per cent, 30 per cent, 50 per cent., 60 per 

 cent, in quantities ranging from 1 c.c. to 5 c.c. per kilo, administered 

 1 to 2)( hours after the introduction of the cannula into the com- 

 mon duct. 



With the exception of experiment XI in the accompanying 

 table (I), the volume secreted immediately after the injection of 

 alcohol into the stomach or into the intestines showed a marked 

 increase as compared ^ with the period immediately preceding the 

 injection of alcohol. In 1 1 of the 12 experiments performed on 

 different dogs, the percentage of increase, as shown in the accom- 

 panying table (I), ranged from 50 per cent, to 365 per cent. In 

 a large proportion of the experiments, in which the dogs were 

 apparently so exhausted that the secretion of bile reached a min- 

 imum, the introduction of alcohol into the stomach or intestine 

 caused a striking improvement. In some experiments alcohol 

 was injected both intravenously and into the intestines. The 

 volume of bile secreted after the intravenous injection indicated a 

 diminished rate of secretion, while in the same animal after the 

 administration of alcohol into the intestines the secreted volume 

 of bile increased 140 per cent, in one experiment and 80 per cent, 

 in another. The solid constituents were likewise markedly in- 

 creased. In one experiment there was an increase of 130 per 

 cent, in the total solids, 1 3 2 per cent, increase of organic matter, 

 and 1 1 5 per cent, increase in the ash, the increase in volume in the 

 same experiment being 140 per cent. In another experiment the 

 total solids increased about 100 per cent, organic matter 108 percent, 

 and ash 60 per cent., the gain in volume being 125 per cent. Of two 

 experiments, the increase in the volume secreted as well as in the 

 amounts of solid constituents was 80 per cent, in one ; in the other, 

 the figures showing percentage increases in the secreted volume, 

 total solids, organic matter, and ash were 160, 185, 195, 112, 

 respectively, indicating that, at least in certain cases, some of the 



