42 (212) Society for Experimental Biology and Medicine. 



Fifteenth meeting. 1 



[Third annual business meeting.] 



Physiological Laboratory of the New York University and Belle- 

 vne Hospital Medical College. February 21, icjo6. President Wil- 

 son in the chair. 



21 (113). "On the intermediary metabolism of lactic acid": 

 A. R. MANDEL and GRAHAM LUSK. 



Administration of phlorhizin to a dog poisoned with phosphorus 

 causes the excretion of dextrose, the mother-substance of lactic 

 acid, and the latter then disappears from the blood and urine. On 

 the other hand ^/-lactic acid (Kahlbaum), when given to a diabetic 

 dog, may be completely converted into dextrose. 



22 (1 14). " The primary factor in thrombosis after injury to the 

 blood-vessels 99 : LEO LOEB. 



No uniformity of opinion exists in regard to the essential pro- 

 cesses leading to thrombosis. According to some authors throm- 

 bosis is essentially due to coagulation of plasma or of cells. 

 Others hold that two factors enter : Agglutination and coagulation. 

 Klemensiewicz and Gutschy expressed the opinion that the primary 

 formation of a fibrinous membrane at the place of injury is necessary. 



We find the same diversity of views in regard to the so-called 

 first coagulation of arthropod blood, which, as the author has 

 already shown experimentally, is identical with thrombosis in that 

 animal. That no explanation of thrombosis has found general 

 recognition so far is due to the fact that microscopic examinations 

 alone, based on staining reactions, are entirely inadequate for a de- 

 cision of this question. Almost all previous work rests mainly on 

 morphological investigation. 



Sahli's work, however, forms an exception. He found that 

 after injection of leech extract into the circulation of a rabbit, 

 thrombi no longer formed around foreign bodies introduced into 

 the blood-vessels. He concluded quite logically that his results 

 prove the correctness of the view of Hanau and others, namely, 

 that thrombosis is a process of coagulation. The results of his 

 experiments are directly opposed to the fact repeatedly pointed out 

 by the author, viz., that agglutination of blood plates occurs in 



1 Science, 1906, xxiii, p. 662 ; American Medicine, 1906, i (N. S. ), p. 33. 



