56 (226) Society for -Experimental Biology and Medicine. 



blood corpuscles of the rabbit are injected into the pleural cavity 

 of the dog, at the end of twenty-four hours an exudate is produced 

 very rich in large mononuclear cells, and, in correspondence, the 

 power of the cells to digest in an acid medium is greater than that 

 of the twenty-four hour aleuronat exudate. 



Lymphatic glands in the neighborhood of the inflammatory 

 exudate, the substernal glands in the case of the pleura, contain 

 at the end of three or more days in greater number larger mono- 

 nuclear phagocytes similar to those found in the exudate at the 

 same stage. Emulsions made from such glands digest in an acid 

 medium and little if at all in an alkaline medium. The digestive 

 power of these glands (measured in cubic centimeters of i/io 11 

 sulfuric acid) is constantly greater than that of glands such as the 

 mesenteric some distance from the seat of inflammation. 



Exp. 1. Exp. 2. Exp. 3. Exp. 4. 



Substernal Glands 7.6 c.c. 11.45 c.c. H-95 c.c. 12.2 c.c. 



Mesenteric Glands — 9.9 c.c. 8.75 c.c. 9.0 c.c. 



Time after injection I day 3 days 4 days 5 days 



The differences in degree of digestion are more significant when 

 it is recalled that the activity of other proteolytic enzymes has 

 been shown to vary in a proportion equal approximately to the 

 square root of the quantity of the enzyme. 



The phagocytic cells of an inflammatory exudate contain two 

 enzymes. One of these ferments, characterized by its power to 

 digest protein in an alkaline medium, is contained in the polynu- 

 clear leucocytes with fine granulation, and since it is derived from 

 the bone marrow may be designated myclo-protease. The second 

 ferment, characterized by its power to digest only in an acid me- 

 dium, in this respect resembling the autolytic ferments of other 

 organs, is contained in the large mononuclear cells of the exudate 

 and is increased in lymphatic glands adjacent to the seat of inflam- 

 mation ; it may be designated lympho-protcasc. 



31 (123). "Experimental myocarditis. A study of the histo- 

 logical changes following intravenous injections of adren- 

 alin ": 1 RICHARD M. PEARCE. (Presented by EUGENE 

 L. OPIE.) 



Intravenous injections of adrenalin in doses of one-tenth cubic 

 centimeter, soon raised to five-tenths and given on alternate days, 



1 Journal of Experimental Medicine, 1 906, viii, p. 400. 



