s 



Scientific Proceedings (77). 



The last method proved more sensitive in the group of known 

 syphilitics than the other procedures tested. Furthermore, a 

 positive result thus obtained proved to be more trustworthy 

 evidence of syphilis than did positive results obtained with the 

 cholesterinized antigen and first incubation at 37° C. 



6 (1184) 



The influence of alkali upon the glycosuria, hyperglycemia and 

 carbon dioxide combining power in human diabetes. 



By J. R. Murlin and L. F. Craver with the Clinical Co-operation 

 of W. L. Niles and Warren Coleman. 



\From the Physiological Laboratory of Cornell University Medical 

 College and the Second Medical Division of Bellevue 

 Hospital, New York.] 



Murlin and Kramer 1 have shown that alkali administered to 

 depancreatized dogs reduces the glycosuria, often lowers the blood 

 sugar, and, especially in partially depancreatized animals, assists 

 in the combustion of glucose. It has been held generally that 

 alkali administered to diabetic patients does not influence the 

 glycosuria 2 or hyperglycemia. A critical study of several cases 

 kept under perfect dietary control in the metabolism ward of the 

 Sage Institute of Pathology in Bellevue Hospital during the 

 past summer seems to show, however, that alkali (1 per cent. 

 Na2C0 3 ) administered by duodenal tube often reduces the gly- 

 cosuria very materially and may likewise affect the hyperglycemia. 



A preliminary study of the blood sugar and carbon dioxide 

 combining power of the whole blood in six patients with diabetes 

 and several normal persons exhibits a striking inverse relationship 

 which is almost proportional. 



Two patients among the eight studied exhibited features of 

 special interest. One (Frank B.) had a normal blood sugar 

 throughout but excreted from 25 to 39 gm. of sugar, regardless of 

 the amount eaten. He is probably a case of renal glycosuria. The 



1 Murlin and Kramer, Journal of Biological Chemistry, 191 6, Proceedings of 

 American Society of Biological Chemists, XXIV, March No., p. i; Full report, Ibid., 

 1916, XXVII, Nov. No. 



2 Von Noorden, Handbuch der Pathologie des Stoffwechsels, II, Berlin, 1907, 

 p. 576. 



