Coagulation Time of Blood. 



19 



3. Closed aseptic intestinal loops in which the blood supply is 

 completely shut off are not incompatible with life. 



4. Bacterial activity plus the necrotic tissue or the results 

 of the action of bacteria on necrotic tissue is the important factor 

 in the rapid death in simple closed intestinal loops. 



5. The normal secretions of the duodenum and jejunum are 

 not toxic when allowed to drain into the abdominal cavity. 



6. Our results do not support the theory of Draper of a normal 

 toxic secretion of the duodenal mucosa, neutralized by the jejunal 

 mucosa, or the perverted secretion theory of Whipple. 



14 (1192) 



The effect of intravenous injections of fresh human serum and 

 of phosphated blood, on the coagulation time of the 

 blood in hereditary hemophila. 



By Thomas Addis. 



[From the Laboratory of the Medical Division of Stanford University 

 Medical School, San Francisco.] 



The coagulation time of the blood in hereditary hemophilia 

 fluctuates in an irregular manner from day to day. Only very 

 pronounced alterations are therefore of value as a guide to the 

 effect of any particular method of treatment. The variations 

 shown in Table I were observed in cases who were not subjected 

 to any treatment. In many instances the changes observed are 

 well beyond the error of the method which was used. Five cubic 

 centimeters of blood were withdrawn from the median basilic 

 vein through a short oiled needle into two or more test-tubes, and 

 the average interval of time required until coagulation had ad- 

 vanced sufficiently to allow of the complete inversion of the tubes 

 without spilling the contents was taken as the coagulation time. 

 The temperature was 37 0 C. Normal blood requires about 13 

 minutes to coagulate under these conditions. Parallel observa- 

 tions with another method showed that reliable results could be 

 obtained with blood from skin puncture when certain details in 

 the manner of collecting the blood were observed. 1 



1 Addis, T., Edin. Med. Journ., 1910, V, 38. 



