20 



Scientific Proceedings (77). 



table 1. 



Variations in the Coagulation Time of Hemophilic Blood Occurring in 

 Cases Not Subjected to Any Treatment. 



Case I. 



Case II. 



Case 



III. 



Date. 



Coag. Time. 

 Minutes. 



Date. 



Coag. Time. 

 Minutes. 



Date. 



Coag. Time 

 Minutes. 



Aug. 21 

 " 22 



" 23 

 " 24 



" 25 



" 26 

 " 30 

 " 31 



Sept. 4 

 5 



" 10 

 " 11 

 19 



" 23 



60 

 53 

 50 

 67 

 66 

 68 

 88 

 96 

 67 

 81 

 55 

 7i 

 65 

 76 



Sept. 19 

 22 

 " 23 



60 

 87 

 70 



Sept. 15 

 " 18 

 " 20 

 " 23 



38 

 54 

 80 

 52 



Variations in coagulation time which were not greater than 

 those illustrated in Table I were noted under the administration 

 by mouth of calcium lactate, sodium chloride and of large quan- 

 tities of raw beef juice. The removal from a vein of 60-70 c.c. 

 of blood once a week had no effect. 



No immediate effect was produced by the intravenous injection 

 of normal horse serum and of antidiphtheritic serum. These 

 sera were all five or more weeks old. In one case a marked 

 prolongation of coagulation time was found three weeks after an 

 intravenous injection of horse serum, but since successive observa- 

 tions were not made during this interval, it is not certain that this 

 was the result of the serum injection. 



The intravenous injection of 15 c.c. of human serum separated 

 from freshly drawn blood ninety-six hours previously was followed 

 within 15 minutes by a striking decrease in the coagulation time. 

 There was a gradual increase in the coagulation time during the 

 next week and on the tenth and twelfth days after the injection, 

 the coagulation time was considerably longer than before the 

 serum was given. Three weeks later the coagulation time was 

 again at its usual level. The details of this experiment are given 

 in Table II. The method of skin puncture was used. 1 Each 

 figure is the average of six estimations. 



