Coagulation Time of Blood. 



21 



TABLE II. 



Variation in the Coagulation Time of Case I Following the Intravenous 

 Injection of Human Serum, Ninety-six Hours Old. 



Coagulation Time. 



Date. Minutes. Remarks. 



Feb. 24 72 Normal coagulation time 10 min. 



Feb. 26 89 



Feb. 28 72 



Mar. 2 3 P.M. 62 



4 P.M. 15 c.c. human serum 96 hours old 



injected intravenously. 



4:15 P.M. 24 



6:00 P.M. 27 



8:00 P.M. 33 



Mar. 5 2:00 A.M. 34 



12 Noon 39 



Mar 6 40 



7 49 



10 59 



12 77 



14 127 



16 114 



17 103 

 20 94 

 22 86 

 24 83 



The intravenous injection of freshly drawn whole blood to 

 which sodium phosphate had been added as an anti-coagulant, 1 

 had the immediate effect of making the coagulation time ten times 

 shorter. But here again as after the injection of fresh serum, this 

 decrease was succeeded by a gradual lengthening of the time. 

 Unfortunately it was not possible to continue the observations 

 beyond the eighth day, so that it is not known whether there was 

 a later increase in the coagulation time beyond the time required 

 before the injection. These results were obtained with the method 

 of venous puncture. They are given in Table III, which also 

 shows another experiment, illustrating the immediate reduction 

 in coagulation time caused by fresh human serum. 



The recalcified oxalated plasmata prepared from blood drawn 

 from Case 1 and Case 2 after the injection of fresh human serum 

 coagulated in a considerably shorter time than the recalcified 

 plasmata prepared from blood drawn before the injection. The 

 rate of formation of thrombin was more rapid after serum injection 



1 One part of 5 per cent, sodium phosphate to three parts of blood. 



