New-Formation of Hemal Nodes. 



39 



observers failed to find any laws governing these fluctuations, and 

 therefore did not attribute any diagnostic significance to this 

 phenomenon. As any antigen and its corresponding antibody 

 will cause fixation of the complement of the blood, it i evident 

 that the reaction is not specific and could not be used instead 

 of accepted methods for diagnosis. However, if this reaction is 

 used in addition to other tests it gives very valuable information, 

 Thus, for instance, in the cases of syphilis treated with salvarsan. 

 the Wassermann reaction may remain positive, whereas our test 

 gives negative reaction as soon as the antigen disappears from the 

 blood. In cases of gonnorhea of many years standing, we ob- 

 tained negative reactions, whereas the cases of short duration or 

 with discharge at present gave positive reactions. 



Thus, the negative outcome of the test seems to be of great 

 value, especially in the face of positive findings by usual methods. 

 Since the positive outcome of this test may be influenced by many 

 different conditions, we hesitate at present to attribute to it any 

 more value than that of a very promising suggestion. We hope, 

 however, to be able by isolating the antigen from its combination 

 with antibody in the blood, to make also the positive phase of the 

 test of more value in determining the circulation of antigen. 



25 (1203) 



The new-formation of hemal nodes in the omentum and mesentery 

 of the dog after splenectomy and ligation of the splenic 

 veins. (Preliminary report.) 



By Aldred Scott Warthin, Ph.D., M.D. 



[From the Pathological Laboratories of the University of Michigan, 



Ann Arbor.] 



The question of the new-formation of splenic or hemolymph- 

 node tissue in the dog after splenectomy has been opened up again 

 by Meyer, 1 who, as the result of the findings of eight dogs examined 

 after splenectomy, at periods of 30, 41, 53, 77, 89, 98, 112 and 

 126 days after the operation, found no changes in the lymph-nodes, 

 either of the nature of a hyperplasia or regeneration. Doubt was, 



1 Journal of Experimental Zoology, 1914. 



