Proteose Intoxications and Body Protein Injury. 45 



with all doses the average effect of intravenous injections of 

 adrenalin on the blood pressure was greater in the rabbits than in 

 the cats both in regard to the height and the duration of the rise. 



We may then conclude that the difference in the effect of 

 instillations is not dependent on greater sensitiveness of the iris 

 of the rabbit and that the greater sensitiveness of the cats' dilator 

 muscle to the action of adrenalin is not shared by all other smooth 

 muscle. 



28 (1206) 



Proteose intoxications and body protein injury. 



By G. H. Whipple and J. V. Cooke. 



[From The George Williams Hooper Foundation for Medical Research 

 and the Department of Pathology, University of California 

 Medical School, San Francisco.] 



Proteose injections in dogs cause well-known clinical reactions 

 — vomiting, diarrhea, temperature reactions, low blood pressure, 

 prostration and after large doses, an excess of antithrombin with 

 incoagulable blood. A single proteose injection — for example one 

 half a lethal dose — causes abrupt clinical reactions in a normal dog 

 with apparent complete recovery within 24 to 48 hours. The 

 nitrogen elimination curve in a fasting dog under such conditions 

 shows a great rise in total urinary nitrogen. The apex of the 

 curve usually falls on the second 24-hour period following the 

 injection. This rise may be over 100 per cent, increase above the 

 mean base line nitrogen level. It does not fall promptly to normal 

 but declines slowly in 3 to 5 days or more toward the original base 

 line. This speaks for a definite cell injury with destruction of 

 considerable protein substance due to a single proteose injection. 

 The disturbance of cell equilibrium is not rapidly nor promptly 

 restored to normal. 



A dog which has received previous proteose injections is some- 

 what immune or tolerant to subsequent injections of proteose. 

 Such dogs, as a rule, show less intense clinical reactions and less 

 rise in the curve of nitrogen elimination following a unit dose of 

 standard proteose as compared with normal or non-immune con- 



