Colostral Serum Therapy. 



55 



lation into the surrounding tissues where it becomes destroyed by 

 the alkalinity of the tissue fluid. Subcutaneous injection of 

 adrenin produces only a slight effect upon the blood pressure. 

 As is well known the bloodvessels of the rabbit's ears are easily 

 visible. We have observed that a subcutaneous injection of 

 adrenin into the lower part of one of the rabbit's ears causes a 

 striking and long lasting constriction of the bloodvessels of the corre- 

 sponding ear. It is this phenomenon which we wish to demonstrate. 

 If the injection is given in the proximity of the central artery, the 

 constriction of the bloodvessels of the entire ear sets in two or three 

 minutes after the injection. If it is given at some distance from the 

 central artery, the pallor develops slowly. In either case the vessels 

 remain more or less strikingly constricted for many hours, some- 

 times even seven hours. Injection of a different solution, saline, 

 lor instance, does not exert such an effect. It is evident that in 

 the case of the ear the adrenin is not destroyed rapidly by the 

 tissues surrounding the bloodvessels. 



35 (1213) 

 Colostral blood-serum therapy. 



By Charles B. Fitzpatrick. 



[From the Research Laboratory, Department of Health, New York 



City, New York.] 



My observations on natural antibodies and healing substances 

 in milk 1 led me to study the transmission of antitoxines in colo- 

 strum. Some buck kids were fed from birth until they were about 

 one month old on the colostrum milk which their mothers gave 

 after delivery. The blood-serum of these young goats was utilized 

 for this study. 



The ingestion of the colostrum of goats by man has disagreeable 

 results. The greatest amount of the immunizing substances both 

 natural and artificial which pass from the nursing mother to the 

 blood-serum of the infant, however, is transmitted by the colo- 



'"The Utilization of 'Reactor' Milk in Tubercle-Medicine," Proc. Soc. Ex- 

 perimental Biology and Medicine, 1915, xiii, pp. 35-37. 



