66 



Scientific Proceedings (79). 



IV. Thirty-one cases having both physical and laboratory 

 evidence of central nervous system disease. Appearance time 

 fourteen to eighty minutes, averaging forty-six minutes. 



In a general way, delay in excretion ran parallel to the severity 

 of the clinical symptoms, but the quantity eliminated has appeared 

 to be more variable. The method may prove of value in detecting 

 instances of organic central nervous system disease in which the 

 ordinary spinal fluid findings are negative, and since the absorption 

 from the subarachnoid space is believed to be through the blood 

 vessels the delays observed may serve to indicate the degree of 

 vascular change. 



42 (1220) 



Analysis of the anaphylactic reaction by means of the isolated 

 anaphylactic lung. 



By W. H. Manwaring and Yoshio Kusama. 



[From the Department of Bacteriology and Immunology, Leland 

 Stanford Jr. University.] 



Analyses of the anaphylactic and immune reactions by means 

 of perfusion experiments with the isolated guinea-pig lung show 

 that we are here concerned with three essential physiological 

 factors : 



(a) Cellular Anaphylaxis or the anaphylactic response of the 

 hypersensitive fixed pulmonary tissues, 



(b) Humoral Anaphylaxis, or the chemical reactions (ana- 

 phylo toxin formation) with the anaphylactic blood elements. 



(c) Humoral Immunity, or the inhibiting and protective action 

 of the immune blood elements. 



In the 14-day anaphylactic guinea-pig, the fatal bronchial 

 spasm is due in part to cellular hypersensitiveness, in part to 

 humoral anaphylaxis. 



In the 4-week anaphylactic guinea-pig, the humoral reaction 

 is always very slight and usually absent. The cellular hyper- 

 sensitiveness, however, is usually greater than that of the 14-day 

 anaphylactic guinea-pig. The fatal bronchial spasm in the 4-week 

 anaphylactic guinea pig is usually due solely to the cellular hyper- 

 sensitiveness. 



