Epinephrin. 



77 



moved just as when ablation of the whole hemisphere is made, 

 (4) the natural history of nystagmus, (5) the development of 

 nystagmus in young animals 1 and (6) the known cerebral localiza- 

 tion of the motor cells, stimulation of which produces ocular 

 movements, it is probable that the quick component of nystagmus 

 is a reflex response, a part of whose path lies through the cerebral 

 hemispheres. The reasons for invoking shock are not clear. 



It is probable also that the quick component of labyrinthine 

 nystagmus has no necessary connection with the labyrinth, but 

 that it is a reflex 2 whose afferent impulses arise from stimulation 

 of the afferent endings in the eye muscles. 3 The cortical end sta- 

 tions of fibers from these afferent endings are, as we now believe, 

 in the temporal region. The quick component of nystagmus has 

 developed along with the greater degree of mobility of the eyes, 

 and brings about the return of the eyes to a position such that the 

 original line of vision is restored when they are deflected too far 

 to one side. 



49 (1227) 



The influence of certain conditions on the rate at which epinephrin 

 is liberated from the adrenals into the blood. 



By G. N. Stewart and J. M. Rogoff. 



[From the H. K. dishing Laboratory of Experimental Medicine of 

 Western Reserve University, Cleveland, Ohio.] 



I. By means of the rabbit intestine and uterus segment tests, 

 we have obtained further evidence that, under our experimental 

 conditions at any rate, the rate of discharge of epinephrin into the 

 blood of the adrenal veins is relatively steady and not easily in- 

 fluenced by such procedures as we have tried ; for example, stim- 

 ulation of the afferent fibers in large peripheral nerves (sciatic 

 and brachial) or asphyxia. This is not because the discharge is 

 already maximal owing to the necessary conditions of the experi- 



1 Prince, American Journal of Physiology, 1917, XIII, p. 308. 



2 Wilson and Pike, International Congress of Medicine, London, 1913, Section 

 XLV, p. 563- 



3 Tozer and Sherrington, Proceedings Royal Society, London, B, LXXXII, 

 1910, p. 450. 



