8o 



Scientific Proceedings (80). 



course contained a very small proportion of serum, gave no meas- 

 urable rise. 



3. Similar results were obtained (with dog's blood to which 

 adrenalin had been added) on segments of rabbit's intestine and 

 uterus. The sediment gave a small inhibition of the intestine and 

 a small increase of tone of the uterus as compared with the serum. 

 The effect of the adrenalin blood was intermediate in amount. 



4. The distribution of the naturally secreted epinephrin in the 

 blood from the adrenal veins (of the dog) was also investigated 

 with the same result. Only the rabbit intestine and uterus were 

 employed, the other methods not being sufficiently sensitive for 

 the small concentrations found in blood. In one experiment the 

 concentration of epinephrin in the blood was assayed at 1 : 8,000,000, 

 in the serum at 1 : 3,000,000. The sediment gave practically 

 nothing. It so happened that the blood used was extremely rich 

 in corpuscles, a circumstance favorable rather than otherwise for 

 testing the point in question, as the serum would be more than 

 ordinarily rich in epinephrin as compared with the blood, if all 

 the epinephrin is contained in the plasma. The proportion of 

 serum by volume in the blood was 36 per cent. On the hypothesis 

 that all the epinephrin was in the serum, this would give 

 1 : 100/36 X 3,000,000, i. e., 1 : 8,300,000 as the concentration 

 in the blood. 



5. When search is being made for the minute quantities of 

 epinephrin present in blood, serum (or plasma) should, in general, 

 be preferred to blood in making the tests. 



51 (1229) 



The influence of intravenous inoculations of cholesterin upon 



blood cells. 



By Oskar Klotz and Mary W. Spencer. 



[From the Pathological Laboratories, University of Pittsburgh, 



Pittsburgh, Pa.] 



Some years ago (1907) Talquist believed that he had found the 

 harmful substance present in the Bothriocephalic latus leading to 

 progressive anemia. The substance which he isolated from these 



