The Parenteral Admnistration of Starch. ioi 



before the tartrate was given, the dose survived was 3.0 grams 

 per kilo. One rabbit only developed albuminuria when this dose 

 was given. In one series of four rabbits three survived such a dose. 

 In another series with 3.5 grams per kilo, one survived and three 

 died, two in 12 and 36 hours and one in 6 days. The resistance 

 was likewise very marked when carrot leaves were fed 4 to 11 

 days before injecting tartrate, but was less than in the case of 

 young carrots, the minimum fatal dose being about 2.5 grams 

 per kilo. The duration of life in this case was 2 to 5 days, the 

 rabbit dying, however, without developing albuminuria. The 

 toxicity when mature or winter carrots were fed was on the con- 

 trary considerably greater, the fatal dose being 1.25 to 1.5 grams 

 per kilo. 



Exactly the same results were obtained with sweet potatoes 

 as with carrot leaves, as 2.5 grams per kilo likewise proved to be 

 fatal, while a dose of 2.0 per kilo failed to produce any nervous 

 symptoms or renal irritation. Sodium tartrate proved to be most 

 toxic when the diet consisted of oats and cane sugar, glucose, or 

 levulose. When 0.5 gram per kilo was injected subcutaneously 

 on this diet, seven out of 8 rabbits died after 2 to 13 days. Symp- 

 toms of renal irritation and nervous disturbances were noticed in 

 these experiments. The toxicity on hay, cabbage or oats was 

 about the same in each case and was approximately twice that on 

 oats and sugar, or about one fourth that on young carrots. The 

 resistance to sodium tartrate on a diet of sugar beets was about 

 half that on young carrots. Experiments with tartrate on cats 

 that received different diets failed to show any marked difference* 

 but when starved for eight days the toxicity was increased about 

 40 per cent. 



63 (1241) 



A note on the parenteral administration of starch. 

 By C. E. King. 



[From the Laboratory of Physiology, University of North Dakota.] 



Very little work has been done on the question of the produc- 

 tion of a protective amylase after the parenteral administration 

 of starch. Most observers agree that the blood normally contains 



