120 



Scientific Proceedings (82). 



such case have we failed to find a discrepancy. The abnormal 

 alveolar/plasma ratio persists for some days. This would make 

 it seem unlikely that the disturbance was due to the fixation of 

 C0 2 by the accession of alkali to the blood. It persists after all 

 obvious hyperpnea is gone, so that an increase of the sensibility 

 of the respiratory center can not be offered as a definite explana- 

 tion as yet. The fault is not in the choice of the Fridericia method 

 as it has also been observed with the Plesch-Higgins method. 

 It seems unlikely that it is dependent on personal factors because 

 of the absolute constancy of its relation to rapid changes in blood 

 reaction and its absence at all other times. We are continuing 

 studies to determine the cause of the phenomenon. 



We believe that alveolar methods do not indicate accurately 

 the reaction of the blood after recovery from acidosis. We also 

 suggest that the value of respiratory quotients at such times 

 may be questionable. 



71 (1249) 



Active immunization with sensitized and non-sensitized bacteria. 



By Homer F. Swift, M.D. and Ralph A. Kinsella, M.D. 



[From the Medical Clinic, Presbyterian Hospital, Columbia Uni- 

 versity, New York.] 



In a previous communication 1 we reported that the serum of 

 rabbits which had been injected with sensitized vaccine or living 

 cultures of Streptococcus viridans, did not contain agglutinins, 

 complement fixing antibodies or protective antibodies. Later 

 similar results were obtained with sensitized vaccines of pneumo- 

 cocci, with the exception that the serum of animals inoculated 

 with sensitized living pneumococci showed a rapid production of 

 these antibodies. We then attempted to determine whether there 

 was evidence of active immunity even though no antibodies could 

 be demonstrated in the serum. It has been found impossible to 

 immunize mice with green streptococci. Rats may be immunized 

 with green streptococci, but the virulence of these organisms is 

 so low that it is impossible to compare the results of immunity 



1 Homer F. Swift and Ralph A. Kinsella, Proc. Soc. Exp. Biol, and Med., 

 1915-16, XIII, 103. 



