122 



Scientific Proceedings (82). 



It is suggested that the immunity is due in part to a tissue 

 immunity and not due entirely to antibodies circulating in the 

 blood serum. 



72 (1250) 



The influence upon the Ehrlich sarcoma of stimulation or de- 

 pression of the oxidative processes in mice. 



By F. D. Bullock, M.D. (by invitation). 



[From Columbia University, George Crocker Special Research Fund, 

 F. C. Wood, Director.] 



As far as the reports in the literature show, no one has investi- 

 gated the effect of drugs which increase or decrease the oxidative 

 processes of the organism upon the transplanted tumors of mice. 



Through the courtesy of Dr. A. S. Loevenhart, both iodozo- 

 benzoic and iodoxybenzoic acids, which are oxidative stimulants, 

 were obtained. These acids were converted into their sodium salts 

 and injected into mice both before and after inoculation with 

 tumor. In one group of animals, sodium iodozobenzoate in doses 

 of 0.015 gm. was injected subcutaneously every day for six days 

 previous to inoculation with tumor, while in a second group the 

 same drug in similar dose was injected for eight days after inocula- 

 tion. A third group received six injections of sodium iodoxy- 

 benzoate in dosage of 0.002 gm. previous to inoculation, while the 

 animals of a fourth group received eight injections of similar dosage 

 after inoculation. A fifth group of control animals remained 

 untreated. 



As an oxidative depressant sodium cyanid was used. One 

 series of animals received seven injections of 0.00062 gm. previous 

 to inoculation, while another received seven injections of similar 

 dosage after inoculation; a third untreated group served as 

 controls. 



All the animals were inoculated by needle with 0.003 g m - °f 

 the Ehrlich mouse sarcoma. 



Neither of these two procedures influenced the percentage of 

 takes or the rate of growth. 



1 Loevenhart, A. S., Harvey Lectures, 1914-15, X, 280. 



