Spontaneous Liberation of Epinephrin. 143 



2. The delayed kidney injury in acute bichloride intoxications 

 has been constantly associated with the development of an acid 

 intoxication. The severity of the damage to the cells of the 

 convoluted tubules and the extent of fatty infiltration in the 

 cells of the ascending limb of Henle's loop show a correlation 

 with the degree of acid intoxication. 



85 (1263) 



Relation of the spinal cord to the spontaneous liberation of 



epinephrin. 



By G. N. Stewart and J. M. Rogoff. 



[From the H. K. dishing Laboratory of Experimental Medicine, 

 School of Medicine, Western Reserve University, Cleveland.] 



1. In acute experiments on cats, anesthetized with urethane, 

 section of the spinal cord in the cervical region caused no demon- 

 strable diminution in the rate of liberation of epinephrin from the 

 adrenals as tested by allowing the adrenal blood collected in a 

 cava pocket to elicit eye-reactions (after preliminary excision of 

 the superior cervical ganglion). Four such experiments were 

 made. The cord section in one of these was between the third 

 and fourth cervical vertebra?, in another opposite the body of the 

 fourth cervical vertebrae, in a third just below the body of the 

 fifth cervical vertebra, and in a fourth cat between the fifth and 

 sixth cervical vertebrae. In the second of these animals the blood 

 was collected from the adrenal vein before and after section of the 

 cord. The epinephrin assay (by rabbit intestine segments) gave 

 the same output of epinephrin per minute after as before the 

 section. The blood flow from the adrenals was much slower after 

 the section, but was correspondingly richer in epinephrin. 



2. In two survival experiments the cord was cut in the cervical 

 region (in one just above the body of the last cervical vertebra, 

 in the other at the level of the body of that vertebra). In the 

 first cat, the superior cervical ganglion had been previously excised. 

 Two days after the cord section adrenal blood was tested by the 

 cava pocket method and gave good eye reactions, indicating 



