152 



Scientific Proceedings (84). 



Our results are briefly as follows: in spite of the fact that at 

 least 95 per cent, of the pancreas was immediately killed by the 

 alcohol-acid mixture, and that the dogs were fed on a diet rich in 

 carbohydrate, yet the great majority of our animals showed no 

 glycosuria or hyperglycemia. Occasionally a faint trace of sugar 

 appeared in the urine. The blood sugar varied in general between 

 0.10 and 0.15 per cent.; in some nervous dogs, which required 

 considerable handling, the blood sugar at times reached 0.20 

 per cent. 



There were two striking exceptions to this general course; 

 two dogs developed a severe diabetes immediately after the opera- 

 tion. In dog 28, which died after 28 days, the urinary sugar 

 varied between 3 and 6 per cent., and the blood sugar from 0.27 to 

 0.40 per cent. This dog showed a gangrenous pancreatitis. The 

 second dog, no. 32, showed a severe diabetes for seven days after 

 the operation, with a glycosuria of 2-5 per cent, and hyperglycemia 

 which reached 0.32 per cent. From the 9th day, the urine was 

 sugar free, though the blood then showed 0.23 per cent, sugar. 

 Within a week the glycemia had fallen to 0.12 per cent. This 

 animal is still alive after 36 days; moreover, this dog showed a 

 complete tolerance for 10 grams dextrose per kilo when fed this 

 amount 21 days after the operation. 



It is important to add that both dogs, but especially the fatal 

 case, were subjected to considerable traumatism during the opera- 

 tion, due to technical difficulties. 



The tolerance for 10 grams of dextrose per kilo when fed with 

 the ordinary mixed diet, was good when tested in five of our dogs 

 21 to 90 days after the operation. One dog excreted no sugar 

 whatsoever; three excreted 0.3-0.7 gram per kilo; the remaining 

 dog excreted 1.5 grams per kilo. 



The feces of all dogs examined for a longer period were large, 

 voluminous and often greasy. Microscopical examination always 

 showed enormous numbers of undigested muscle fibers, the cross 

 striations being clearly visible as a rule. Starch granules varied 

 in quantity, often large amounts were present, at other times the 

 iodine test showed relatively few. Fat also varied considerably; 

 after feeding 50 grams of lard fat drops were abundant; after 

 smaller amounts often no fat drops were seen. Such variations 



