168 



Scientific Proceedings (84). 



Serum from rats immune to the Flexner-Jobling carcinoma was 

 extracted with chloroform in order to remove the lipoids which, 

 as has been demonstrated by Jobling and his co-workers, inhibit 

 the proteolytic ferments present in that fluid. The lipoid-free 

 serum was injected subcutaneously into a group of 17 rats in 

 doses of 1 c.c. for seven successive days. Three days after the 

 last injection, these animals and a group of seven controls were 

 inoculated with 0.003 S m - °f the Flexner-Jobling rat carcinoma. 



Three weeks after inoculation, the animals injected with lipoid- 

 free serum showed 100 per cent, takes as compared with 85 per 

 cent, in the controls. It may be concluded, therefore, that lipoid- 

 free serum, like non-lipoid-free serum, when obtained from im- 

 mune animals, does not cause passive immunity. 



97 (1275) 



Relative utilization of free palmitic acid, glyceryl palmitate and 

 ethyl palmitate by dogs. 



By J. F. Lyman (by invitation). 



[From the Dept. Agr. Chem., Ohio State University and Sheffield 

 Laboratory of Physiological Chemistry, Yale Univ.] 



Digestibility of fats depends on several factors which may 

 be grouped as: (1) mechanical, e. g., melting point which deter- 

 mines the rate of gastric discharge 1 and, to a considerable extent, 

 the degree of emulsification; and (2) chemical which determines 

 the character of the products of digestion and the rate of hydroly- 

 sis, certain esters of fatty acids, e. g., cetyl palmitate, 2 being 

 attacked very slowly by pancreatic lipase. There is strong 

 evidence for the belief that unchanged esters in a finely emulsified 

 form can not be absorbed by the intestinal mucosa. 3 The facts 

 presented here support this view and agree with the thesis of 

 Terroine 4 that absorption of fats is limited by the rapidity of 

 hydrolysis. 



1 Tangl, F. and Erdelyi, A., Biochem. Zeitschr., 34, 94. 



2 Munk, I., Archiv.f. (Anal, u.) Physiol., 1890, 581. 



3 Bloor, W. R., J. Biol. Chem., 15, 105, 1913. 



4 Terroine, E. F., J. de physiol., 191 1, 695. 



