Passive Cellular Anaphylaxis. 



173 



100 (1278) 



Types of anaphylactic reaction. 



By W. H. Manwaring and Harold E. Crowe. 



[From the Department of Bacteriology and Experimental Pathology, 

 Leland Stanford Jr. University.] 



Study of isolated anaphylactic lungs by perfusion methods 1 

 shows that there are three types of pulmonary anaphylactic 

 reaction : 



(a) Bronchial Anaphylaxis, or the spasmodic contraction of 

 the bronchial musculature, unassociated with recognizable changes 

 in the pulmonary blood vessels. This type of reaction is illus- 

 trated by the lungs of actively sensitized and actively immunized 

 guinea pigs, and by the lungs of guinea pigs passively sensitized 

 with homologous serum. 



(b) Vascular Anaphyalxis, or the spasmodic contraction of the 

 pulmonary blood vessels, usually accompanied with edema. The 

 vascular reation is usually followed by a mild bronchial reaction. 

 This type of reaction is illustrated by the lungs of guinea pigs 

 passively sensitized with heterologous serum, and by the reaction 

 of normal lungs to certain protein split-products and incubated 

 blood mixtures. 



(c) Pseudo- Anaphylaxis, or the plugging of the pulmonary 

 blood vessels with thrombi and agglutinated corpuscle masses. 



101 (1279) 

 Passive cellular anaphylaxis. 



By W. H. Manwaring and Harold E. Crowe. 



[From the Department of Bacteriology and Experimental Pathology, 

 Leland Stanford Jr. University.] 



Tests of passively sensitized guinea pigs, by perfusion methods, 

 show that the cellular reactions of lungs passively sensitized with 

 homologous serum are apparently identical with those of actively 

 sensitized lungs. 



1 W. H. Manwaring and Yoshio Kusama, Journ. Immunology, II, 1917, 157. 



