8 



Scientific Proceedings (35). 



physical methods, but the conductivity of blood slowly falls as the 

 hemoglobin is liberated from the corpuscles. The inhibiting effect 

 of blood serum upon autolysis seems to be less readily destroyed 

 by heat than is usually estimated. 



These experiments were performed with the object of ascer- 

 taining whether or not the contention of Blum as well as of 

 Eppinger, Falta and Rudinger, that adrenalin stimulates the con- 

 version of fat into dextrose, is well founded. On careful analysis 

 of their data, one may find every reason to believe that the animals 

 used for their adrenalin experiments were not glycogen free, and 

 that the extra sugar eliminated after the administration of adrenalin 

 did not come from the ingested fat, but from glycogen or from the 

 sugar of the blood. 



If a phlorhizinized animal be exposed to cold and rendered 

 glycogen free, any intraperitoneal injection of adrenalin ought to 

 be followed by an extra elimination of sugar and a rise in the 

 D : N ratio, provided the theory of the conversion of fat into 

 carbohydrate is true. That this is not the case will be seen from 

 the accompanying protocols. 



5 (415) 



The influence of adrenalin in phlorhizin diabetes. 



By A. I. RINGER. (By invitation.) 



\_From the Physiological Laboratory of the New York University 

 and Bellevue Hospital Medical College .] 



March 6, 1909. 

 March 7, 1909. 

 March 8, 1909. 



Dog No. 5. 



Dog fasting. 

 Dog fasting. 



2 gm. of phlorhizin injected at 8 A. M., 3:30 P. M. 

 and 10 P. M. 



March 9, 1909. 



2 gm. of phlorhizin injected at 8 A. M., 3:30 P. M. 

 and 10 P. M. At 5:15 P. M. the dog was given 

 a bath at a temperature of 8° C. for 30 minutes 

 and while wet was placed in a cold room for 5^2 

 hours. 



March 10, 1909, 9:30 A. M. 

 March 10, 1909, 10:30 A. M. 



2 gm. phlorhizin injected subcutaneously. 

 Catheterized and bladder washed. 

 Weight of dog 9.12 kg. 



