Influence of Adrenalin in Phlorhizin Diabetes. 9 



Table I. 



Time. No. of Hrs. Total N. N per Hour. Total D. D per Hour. D : N. 

 10:15 A - M -~ 



1:15 P. M. 3 1.57 0.523 5.168 I.723 3:29 



1:15 P. M. 0.009 g m - °f adrenalin injected intraperitoneally. 

 1:15 P. M.- 



8:45 A.M. 1 19^ 8.073 0-4H 25.928 1.33 3:21 



This animal was kept in a cold room for five and a half hours 

 following a period of four days' starvation, inclusive of two days 

 of phlorhizin diabetes. This apparently rendered the animal gly- 

 cogen free. Administration of adrenalin produced no increase in 

 the elimination of sugar and no change in the D : N ratio. 



Dog No. 7. 



April 10, 1909. Dog fed last. 



April II, 1909. Dog starving. 



April 1 2, 1909. Dog starving. 



April 13, 1909. Dog starving. 2 gm. of phlorhizin injected subcutaneously at 



8:50 A. M., at 4 P. M. and 11 P. M. 

 April 14, 1909. Dog starving. 2 gm. of phlorhizin injected subcutaneously at 



8:50 A. M., at 4 P. M. and 11 P. M. At 5 P. M. dog given a 



cold bath at a temperature of 5 0 C. for 30 minutes, and while 



wet placed in cold room for the night. 

 April 15, 1909. 8:50 A. M. 2 gm. of phlorhizin injected subcutaneously. 



April 15, 1909. 10:25 A - M. catheterized and bladder washed. Dog's weight, 



8.76 kg. 



Table II. 













c 





H 









f Hrs. 









3 



O 





3 

 O 







Time. 



~6 



Condition. 





X 



u 



Q 



u 





Remarks. 





0 



0 



'u 







a. 





V 



a. 



55 







0 

 S3 



V 



Ph 





0 

 H 





0 

 H 



a 



0 





April 15, 1909. 





















10:25 A.M. -3:25 P.M. 



5:00 



I. 



Phlorhizin. 



2.264 



Q.453 



7.248 



1.449 



3-2 





3:25 P. M.-8:25 A. M. 



17:00 



II. 



Adrenalin and 

 phlorhizin. 



6.297 



o.37 



30.176 



i-775 



4-79 



At 3:25 P. M. 

 0.005 g m - of 

 adrenalin in- 

 jected intra- 



April 16, 1909. 



















peritoneally. 



















8:25 A. M.-3:40 P. M. 



7:15 



III. 



Phlorhizin. 



2.973 



0.41 



9-37° 



1.29 



3-12 





3:40 P. M.-8:40 P. M. 



17:00 



IV. 



Adrenalin and 

 phlorhizin. 



7.129 



0.419 



23.92 



i-4°7 



3-35 



At 3:40 P. M. 

 0.005 gm. of 

 adrenalin in- 

 jected intra- 

 peritoneally. 



Throughout the course of the experiment the phlorhizin was injected regularly at 

 8:00 A. M., 3:45 P. M. and 11:55 P- M - 



1 At 4:10 P. M. and 10:45 P- M. 2 gm. of phlorhizin were injected subcutaneously. 



