3Q 



Scientific Proceedings (36). 



entering air found an obstruction or stenosis shortly after the in- 

 jection of the toxic dose. 



Autopsy showed the typical picture of the lungs : trachea is 

 clear, lungs are well distended, almost forming a cast of the tho- 

 racic cavity ; there is failure to collapse upon opening the chest and 

 excising the lungs ; pieces cut off from the lung do not collapse, 

 but show on pressure a good amount of air and practically no 

 fluid ; blood in lungs and heart is black. 



20 (430) 



Anaphylactic " shock " in the dog. 1 

 By RICHARD M. PEARCE and A. B. ElSENBREY. 



[From the Carnegie Laboratory of the New York University and 

 Bellevue Hospital Medical College.] 

 The observation concerning the blood pressure here offered is 

 not original in that the condition of low blood pressure in anaphy- 

 lactic shock has previously been described by Biedl and Kraus. 2 

 The phenomena of anaphylactic " shock " in the dog are, however, 

 so different from anaphylactic death in the guinea pig that it seemed 

 to Drs. Auer and Lewis 3 and ourselves desirable, that our work, 

 though as yet incomplete, should be presented at this time. In 

 the dog the chief disturbance which can be demonstrated by 

 physiological methods is a sharp fall in blood pressure (50 to 70 

 mm. Hg) which continues for hours, resembling in this respect shock 

 due to other conditions. This is unaccompanied by disturbance in 

 heart rate or by respiratory disturbance, other than that due to the 

 medullary anemia consequent upon the low arterial pressure. 

 From this condition the dog eventually recovers. Death has not 

 been observed in our experiments and Biedl and Kraus state that 

 the animals recover. The recovery from the low level of pressure 

 is very slow, frequently no change being observed in half an hour ; 

 at other times the upward trend begins in less time. 



1 Aided by a grant from the Rockefeller Institute for Medical Research. 



2 Biedl, A., and Kraus, R., Experimentelle Studien iiber Anaphylaxie, Wiener 

 klin. Woch., 1909, xxii, 363. 



3 Auer, J., and Lewis, P. A., Acute Anaphylactic Death in Guinea Pigs. Its 

 Cause and Possible Prevention ; a Preliminary Note. Jour, of the American Med. 

 Assn., 1909, liii, 458. 



