Cause of Serum Anaphylactic Shock. 



35 



ministering pure oxygen, 43 per cent., and by administering pure 

 oxygen along with chloralhydrate and adrenalin, even 66 per cent. 

 Almost invariably the life may be prolonged, the pigs eventually 

 dying from low blood pressure and not from acute asphyxia. 



The pigs used in these experiments were sensitized by injecting intraorbitally 0.01 

 c.c. of horse serum. Young pigs, weighing about 300 grams, were injected with 0.5 

 c.c. of the same horse serum after having been sensitized about 30 days. Pigs were 

 never used sooner than 21 days from the time of injecting the first dose of serum. All 

 injections, except the sensitizing one of serum, of epinephrin and of atropin were made 

 into a special canula tied in the jugular vein. The epinephrin and atropin were usually 

 injected intraperitoneally. 



Table I. 



Atropin Sulphate 0.01 Milligram per Gram of Body Weight. 



No. 



Lived. 1 



No. 



Controls Lived. 



61 



4 minutes. 





/ 



64 



5 " 







66 



5 " 







68 



5 " 







70 



4 " 







132 



23 



136 



5 minutes. 



135 



+ 1 



150 



4 " 



139 



140 minutes. 



151 



3 " 



143 



+ 



152 



15-16 hours. 



145 



16 minutes. 



153 



3 minutes. 



155 



4 " 



156 



5 " 



158 



+ 



159 



+ 



161 



+ 



162 



.+ 



164 



4 minutes. 



1 65 



4 minutes. 



4 out of 14 lived. 



Table II. 



Chloralhydrate -f- Urethane and Epinephrin. 



No. 



Lived. 1 



No. 



Controls Lived. 1 



107 



+ 



"5 



5 minutes. 



108 



5 minutes. 



116 



4 " 



I09 



.+ 



117 



5 " 



I IO 



5 minutes. 



118 



5 " 



III 



6 " 



119 



5 " 



112 



+ 



120 



+ 



I«3 



+ 



121 



5 minutes. 



114 



5 minutes. 



122 



4 " 



125 



5 " 



I23 



3 " 



127 



6 " 



I24 



5 " 



128 



.+ 



126 



+ 



I30 



9 minutes. 



I29 



6 minutes. 



5 out of 12 lived. 2 out of 12 lived. 



1 The sign -f- in these tables indicates complete recovery, the animal being kept for 

 observation a week or longer. The number of minutes given in the second column is 

 the interval of time between the moment of injecting the killing dose of serum and the 

 final gasp. 



