74 



Scientific Proceedings (36). 



of growth, and this though the one was squamous in type, the 

 other adenomatous. So perfect was the apposition of cells that 

 but for the sharp transition from one tissue to another, an observer 

 in ignorance of the conditions of experiment could well believe 

 that here had occurred a metaplasia. The fact thus experimentally 

 proven that cancerous and normal epithelium can secondarily unite 

 must not be forgotten in judging instances of apparent metaplasia 

 at the edge of tumors. 



44 (454) 



Vaughan's split products and unbroken proteins. A compar- 

 ative study of their effects. 



By EDWIN J. BANZHAF and EDNA STEINHARDT. 



[From the Research Laboratory, Department of Health, 

 New York City.] 



The following is a brief summary of our results : 



Comparing the Action of Vaughan's Egg-white Poison to 

 Unbroken Protein. 



1. Inoculations of the unneutralized acid poison into normal 

 guinea pigs gave the same picture as that of the unbroken protein 

 when inoculated into sensitized guinea pigs, whether the poison 

 was given intraperitoneally or intracerebrally. The filtrate from 

 the neutralized poison injected intracardiacally also gave typical 

 symptoms. 



2. Effect of Heat. — The egg-white poison was not affected 

 when heated to ioo° C. for 15 minutes; heated to 120 0 C. for 

 15 minutes it was reduced, but its toxic action not completely 

 destroyed. 



3. Chloral Hydrate. — Normal guinea pigs under the influence 

 of chloral were completely protected against one and a quarter 

 fatal doses of the poison. If two or more fatal doses are given 

 death results. Chloral mixed with the poison, and then given, 

 caused irregular results which was interpreted as meaning that 

 there is no chemical union of the chloral and poison in vitro. We 

 assume that the chloral protects by union with certain vital cells. 



4. Lecithin (Egg) Effect on Serum Anaphylaxis. — Emulsified 

 with the serum and the resulting emulsion injected into serum 



