Sensitization to Tubercular Rabbit-Serum. 77 



should rather be compared to the rabbit. The rabbit does not 

 show the explosive anaphylaxis of the guinea pig, unless the inoc- 

 ulation is given intravenously. The occurrence of this in man is 

 rare and under conditions not yet understood and not explainable 

 by the guinea pig. This occurrence is occasionally shown after 

 the first injection of serum. 



The ordinary serum sickness in man is not grave, nor need 

 the Arthus phenomenon in the rabbit be grave. Therefore, any 

 attempts at finding a method of antianaphylaxis which does not 

 resensitize, for practical purposes, in man should be tried out in 

 the rabbit as well as the guinea pig. 



We wish to thank Dr. Vaughan for his generosity and kind- 

 ness in sending us his split products, and for his courtesy in per- 

 mitting one of us to finish our work in his own laboratory. 



45 (455) 



Notes on sensitization with tuberculin to tubercular rabbit- 

 serum. 1 



By J. P. ATKINSON and 0. B. FITZPATRICK. 



[From the Chemical and Research Laboratories, Department of 

 Health, New York City.] 



These notes are some of the results of our study of sera, toxins 

 and related substances. We have noted by means of the kymo- 

 graph the changes in pressure and respiration produced when we 

 injected into normal dogs, treated with tuberculin or other toxic 

 substances, the sera of normal and diseased animals. A number 

 of interesting facts were found in this way, regarding substances in 

 the serum of animals having tuberculosis, which we think worth 

 reporting. 



The tubercular rabbit serum with which these results were ob- 

 tained, was drawn from rabbits which had been infected 35 days 

 previously with a virulent culture of bovine tuberculosis injected 

 intravenously. The serum was defibrinated and separated centri- 

 fugal ly. 



l This paper was presented by title at the meeting of the American Association for 

 the Advancement of Science, Dec. 27, 1909. 



