Mechanism of Depressor Action of Dog's Urine. 8i 



48 (458) 



Remote results of the replantation of the spleen. 



By ALEXIS CARREL. 



On February 24, 1908, the spleen of a large dog was extir 

 pated, then replanted and the circulation reestablished after an 

 interruption of forty -four minutes. On June 21, 1909, the abdo- 

 men was reopened and the spleen found normal. The dog was in 

 excellent health. On November 1, 1909, the animal died at the 

 farm. The spleen was normal from a microscopical and macro- 

 scopical standpoint. The anastomoses of the vessels were almost 

 invisible. 



This experiment shows that a spleen extirpated and replanted 

 remains in normal condition for more than twenty months after 

 the operation. 



49 (459) 



The mechanism of the depressor action of dog's urine with 

 some observations on the antagonistic action 

 of adrenalin. 



By RICHARD M. PEARCE and ARTHUR B. EISENBREY. 



\From the Carnegie Laboratory of New York University .] 



Summary. — The intravenous injections of dog's urine into the 

 dog causes an abrupt but transient lowering of blood pressure, 

 varying from 20 to 90 mm. Hg (usually 40 to 70), not accom- 

 panied by disturbance of heart action and with little respiratory 

 disturbance. Section of the spinal cord, vagi, cervical sympathetic 

 and splanchnic nerves and destruction of cceliac ganglia and solar 

 plexus individually or collectively does not abolish the depressor 

 action. Physiological and pharmacological experiments based on 

 Dixon's studies of the action of apocodeine show that when the 

 nerve endings are so paralyzed by apocodeine that adrenalin causes 

 little or no reaction, the urine also has no effect. Likewise, in 

 normal animals, and in those with central vaso-motor influence 

 eliminated, the action of urine is antagonistic to that of adrenalin and 

 barium and during the increased pressure due to electrical stimu- 



