82 



Scientific Proceedings (36). 



lation of the nerves of the splanchnic area, the urine causes a fall 

 in pressure. 



From these observations it is concluded that the urine lowers 

 pressure through its paralyzing effect on the endings of the vaso- 

 motor nerves. 



Dog's urine in doses of three cubic centimeters given intra- 

 venously may be used in physiological and pharmacological 

 experiments to produce an abrupt and marked but transient fall in 

 pressure with no secondary effect, in the same way that adrenalin 

 is used to produce a corresponding rise in pressure. 



The physiological antagonism between urine and adrenalin, 

 which evidently act on the same anatomical structures, suggests 

 the possibility that the depressor substance of urine represents a 

 body which previous to its elimination may have a regulatory in- 

 fluence on the circulation directly opposed to that of the secretion 

 of the adrenal gland. 



(50) 460 



On the elimination of bacteria from the blood through the 

 wall of the intestine. 



By ALFRED F. HESS, M.D. 



Last year in a paper presented before this Society on, " Anti- 

 peristalsis in its relation to tubercle bacilli and other bacteria in the 

 alimentary tract," I noted that bacteria which are injected into the 

 blood current of rabbits could be recovered by culture from the 

 contents of the small intestine. Since then I have followed this 

 problem further, investigating the path by which the bacteria enter 

 the alimentary tract, and, although the work is not completed, 

 I have arrived at certain definite conclusions. 



It has been shown by previous workers that some soluble 

 poisons, notably morphine and snake venom, are excreted from 

 the blood through the stomach. It has likewise been demonstrated 

 that various salts, mainly soluble salts, such as strontium or lithium 

 chloride, may be found in the intestine following intravenous injec- 

 tion. It is most probable that the authors of these experiments 

 are correct in deducing that these salts have traversed the wall of 

 the intestine ; however, it should be noted, that in none of these 



