Production of Tabardillo in Monkeys. 85 



sight of the test organism. It was found that the bacteria were 

 excreted in large numbers by the bile. They were also found to 

 a less degree in the urine ; however, no extended quantitative 

 estimations were made in this regard. 



We have not been able to demonstrate the way by which the 

 bacteria pass from the blood or lymph through the intestinal 

 mucosa ; whether unaided or with the help of the leucocytes. 

 The experiments are being continued in this direction. 



51 (461) 



A report on the production of tabardillo, or Mexican typhus 

 fever, in monkeys. 



By JOHN F. ANDERSON, Director Hygienic Laboratory, and 

 JOSEPH GOLDBERGER, Passed Assistant Surgeon, U. S. Public 

 Health and Marine-Hospital Service, Washington, D. C. 



It has been found that at least two species of monkeys, the 

 Macacus rhesus and Cebus capuchinus, are susceptible to infection 

 with tabardillo or Mexican typhus fever by direct inoculation with 

 blood from human cases of this disease. 1 An attack of the disease 

 in the monkey, produced by blood inoculation directly from man, 

 induces a definite immunity to a subsequent inoculation with viru- 

 lent blood. 2 Two monkeys, one a rhesus and the other a capu- 

 chinus, which were tested for their immunity 23 and 30 days re- 

 spectively after the subsidence of their fever, were found to be im- 

 mune to inoculation with large doses of virulent blood. Some of 

 the same blood inoculated into two untreated monkeys produced, 

 after an incubation period of eight days, a febrile curve similar to 

 that of human cases of tabardillo. Blood taken from one of these 

 animals on the sixth day of the fever and used for passage into 

 another monkey, caused, after an incubation period of seven days, 

 a similar febrile curve. 



The blood of a Macacus rhesus infected from a human case 



1 Anderson, John F., and Goldberger, Joseph, A note on the etiology of "tabar- 

 dillo," the typhus fever of Mexico. Public Health Reports, Dec. 24, 1909, XXIV, 

 1941. 



2 Anderson, John F., and Goldberger, Joseph, On the infectivity of tabardillo, or 

 Mexican typhus, for monkeys and studies on its mode of transmission. Public Health 

 Reports, Feb. 18, 1910, XXV. 



