SCIENTIFIC PROCEEDINGS. 



Abstracts of the Communications. 



Thirty eighth meeting. 



Cornell University Medical College. April 20, ipio. President 

 Morgan in the chair. 



52 (462) 



On the neurocytologic changes in shock, infection, Graves' 

 disease, and certain drugs, with a note on fear in rabbits. 



By GEORGE W. CRILE, M.D. 



In a series of observations on the neurocytes of the cortex, the 

 cerebellum and the medulla in shock, infection, Graves' disease, 

 iodoform, strychnia and alcohol poisoning, these cells, principally 

 in the fatal cases, showed a marked alteration in the nucleus- 

 plasma relation and in the size of the cell. 



In the infections, in Graves' disease, in iodoform poisoning and 

 in shock, these changes while varying greatly were in some degree 

 seen in most of the cells. In alcohol and strychnia poisoning 

 some cells were extremely altered while others were but slightly 

 or not at all changed. The changes were studied by counting and 

 measurement and compared with the normal. Due allowance was 

 made for the great variation in the normal. A study of a large 

 series of normal animals served as a basis for comparison. For 

 example, in the normal no cell showing destruction of the nucleus 

 and nucleolus with rupture of the cell membrane was observed, 

 while in the fatal cases from the various diseases studied, there 

 were many such cells. The tissue was all taken fresh, much of it 

 was taken during life and dropped immediately in the fixative 

 solution. 



Frightened rabbits subjected to no trauma and no exercise 

 showed almost complete prostration. Their brains in contrast 



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