88 



Scientific Proceedings (38). 



with normal animals took a much deeper Nissl stain and showed 

 a disturbance of the nucleus-plasma relation and size of the cells. 



53 (463) 



Further observations on hemolysis in cancer. 

 By GEORGE W. CRILE, M.D. 



This note is based on a study of fifty-two cases. Blood from 

 three normal individuals is used for each test. With each there is 

 a control heated to 55 0 C. for ten minutes and also a salt control. 

 A hemolytic reaction in one or more tubes is counted as a positive 

 test. Of the cases offering a fair surgical risk, 82 per cent, showed 

 a positive reaction ; of the advanced cases 39 per cent, showed 

 reaction. Of these all but one showed reverse hemolysis. These 

 results conform with my former tables. The total number thus 

 far observed is three hundred and one. In a large number of ob- 

 servations upon surgical patients other than those with cancer or 

 tuberculosis, there is rarely a hemolytic reaction. In tuberculosis 

 the reaction, when present, is always reverse. In chronic infection 

 there is, in about ten per cent., a direct hemolysis. Among 

 apparently normal individuals, hemolysis occurs in about two per 

 cent. 



We conclude that hemolysis occurs rarely in normal individuals, 

 occasionally in routine surgical patients excepting those with tuber- 

 culosis and cancer. In active tuberculosis it is the rule and is 

 always of the reverse type. In advanced cancer there is hemol- 

 ysis in about two out of five patients and in these the hemolysis 

 is usually reverse. In the operable stage of cancer among about 

 four out of five patients direct hemolysis occurs. Hemolysis is 

 therefore additional evidence of cancer, but in no sense specific. 



54 (464) 



On the behavior of autodermic and isodermic skin 

 grafts in cancer. 



By GEORGE W. CRILE, M.D. 



I have observed in cases having growing cancers that isoder- 

 mic grafts of skin from husband and from son caused a marked 

 local reaction, characterized by excessive exudation, edema, red- 



