Serum Anaphylaxis in Guinea Pigs. 



103 



tion of three lobes. The consolidation is quite similar in char- 

 acter to that occurring in lobar pneumonia of human beings. The 

 lesion is a diffuse and evenly distributed (not patchy) ; exudative 

 inflammation is attended by hemorrhage and the formation of fibrin. 

 The pneumococci multiply in the affected part and they have been 

 found to persist in those animals which were allowed to live 

 longest (six days). In the nine animals which were killed the lesion 

 was confined to the right lung. In the two which died there was 

 involvement of both lungs. One died two days after the injection 

 of a large amount of culture. Three lobes were completely con- 

 solidated and there was a generalized fibrino-purulent pleurisy and 

 pericarditis and septicemia. The other animal, which had fever 

 before the injection was made, died at the end of six hours. There 

 was a generally distributed congestion and edema of both lungs, 

 consolidation of one-half of the posterior right lobe and septicemia. 

 None of the animals which were killed had septicemia. 



Considering the regularity with which pneumonia has been thus 

 produced it would seem that the method should afford valuable 

 opportunity for studying pneumonia experimentally. 



64 (474) 



The effects of resection of one vagus upon serum anaphylaxis 



in guinea-pigs. 



By JOHN AUER. 



[From the Department of Physiology and Pharmacology of the 



Rockefeller Institute^ 

 In a previous communication by Lewis and myself 1 it was 

 demonstrated among other things that the death of guinea-pigs in 

 immediate anaphylaxis was due to the production of a stenosis in 

 the pulmonary air passages so that air neither left nor entered the 

 lung and we brought forward evidence which pointed to a tetanic 

 contraction of the muscles of the bronchioles due to peripheral 

 action as the immediate cause of this stenosis. This view has since 

 been shared by Anderson and Schultz 2 and by Biedl and Kraus. 3 



1 Auer and Lewis: Jour, of the Amer. Med. Assoc., 1909, liii, 458. Auer and 

 Lewis : Jour, of Exper. Med., 1 910, xii, 151. 



2 Anderson and Schultz : Proc. of the Soc. for Exper. Biol, and Med., 1910, vii, 



34- 



3 Biedl and Kraus : Wiener k tin. Woch., 1910, xxiii, 385. 



