Specific Dynamic Action of Protein. 



137 



organism which could not be used as power for the living mechan- 

 ism. If this were true then a considerable increase in the output 

 of carbon dioxide would follow the administration of glutamic acid 

 superimposed upon a regular standard diet. Alanin, which Ringer 

 and the writer have shown to be completely convertible into dex- 

 trose, should show no specific dynamic action, whereas tyrosin 

 with its many cleavages before it reaches a stage for use in meta- 

 bolism might show a pronounced increase in carbon dioxide output. 



From the experiments at hand no specific dynamic action can 

 be shown even after giving large quantities of amino-acids, and 

 there is not even a rise in carbon output which can be interpreted 

 as due to "Darmarbeit" or intestinal work in the sense of Zuntz. 

 The "standard diet" was given in two portions daily and con- 

 sisted in 



Grams. Grams C. 



Cane sugar 100 42.1 



Fat ( + fat in meat) 21.0 16.0 



Meat (1 g. N) 33.4 3.3 



Total C 61.4 



The results are given in the following table. The dog was 

 kept at a temperature of 30 0 C. in the chamber of a Pettenkofer- 

 Voit respiration apparatus for a period of about 22 hours daily. 



Date. 



Ingesta. 



Nin 

 urine. 



C in 

 respiration. 



1908 









I, XII 



Dextrose, 40 g. 



3-55 



46.56 



2 



20 g. -falanin 15.9 g. (2.5 g. N) 



6.39 



47-13 



IOIO 









21, IV 



Standard diet 



2.02 



64.25 



22 



+24 g. glutamic (2.28 g. N) 



358 



59-00 





in interim 







28 



" +24 g. tyrosin (2.03 g. N) 



1.68 



57-72 



29 



2.78 



58.02 





Interim, fasting, ordinary diet, standard 









diet 







13. v 



Standard diet 



1. 19 



59-24 



14 



1 " " +40 g. glutamic (3.82 g. N) 



3-90 



57-78 



IS 





2.24 



54-31 



16 



" +35 g- glutamic (3.41 g. N) 



3-32 



52-25 



17 



" +3° g- glutamic (2.85 g. N) 



425 



58.88 



'Small amount vomited (containing 0.2 g. N). 



