The Distribution of Blood in Shock. 



139 



87 (497) 



The metabolism of the purines in man. 

 By LAFAYETTE B. MENDEL and JOHN F. LYMAN. 



[From the Sheffield Laboratory of Physiological Chemistry, Yale 



University.] 



Adenine, guanine, hypoxanthine and xanthine were fed at inter- 

 vals to two subjects living on a constant purine-free diet. The 

 effects of the administration of these purines (1 to 1.5 grams) on 

 various metabolic functions, especially the partition of nitrogen in 

 the urine, was reported. The output of urinary purines is sum- 

 marized here: 





Purine fed. 



Nitrogen in 

 purine 



nuclens fed 

 grams. 



Increase in nitro| 

 Uric acid. 



r en eliminated as 

 Purine bases. 



gram. 



per cent. 



gram. 



per cent. 





Hypoxanthine, 



O.387 



.248 



64 



.015 



4 



WWH -f 



Xanthine, 



O.369 



.196 



53 



.009 



2 



Guanine, 



1. 114 



•347 



31 



•037 



3 





Adenine, 



O.414 



■153 



37 



.015 



3-6 





Hypoxanthine, 



O.387 



.219 



56 



.009 



2 



JFL | 



Xanthine, 



O.369 



.170 



46 



.004 



1 





Guanine, 



1. 114 



.217 



19 



.030 



2.7 





Adenine, 



O.414 



.126 



30 



.014 



3 



From the numerous data reported, the authors conclude that all 

 of the familiar purines may lead to an increase in exogenous uric 

 acid in the urine of man, with (quantitatively) little influence on 

 the elimination of purine bases. In contradiction to the recent 

 suggestion of Plimmer, Dick, and Leib, 1 they interpret their proto- 

 cols to support the view that uric acid is a stage in the metabolism 

 of exogenous purines, rather than an expression of leucocyte meta- 

 bolism. 



88 (498) 



The distribution of blood in shock. 



By E. P. LYON and J. L. SWARTS. 



[ From the Physiological Laboratory of St. Louis University.] 

 An effort has been made to determine the percentage of blood 

 in different organs before and after shock. About fifteen animals 



1 Jour. of Physol., 1909, xxxix, 98. 



