140 Scientific Proceedings (39). 



(dogs) have been used so far. Under Grehant's anesthetic, the 

 arterial blood pressure was determined. Then, under conditions 

 of high blood pressure, certain organs, or parts of organs, were 

 suddenly ligatured or clamped off from the circulation, and then 

 removed with their blood content. The animal was then allowed 

 to go gradually into a state of "shock" (for our purposes, indicated 

 by a low pressure) or was rapidly reduced to that state by con- 

 cussion or burning. Then companion organs or parts were simi- 

 larly clamped off and excised. The organs were weighed, cut up 

 into fine pieces and extracted, the blood content being determined 

 by Welcker's method. In taking the abdominal organs, we usually 

 proceeded in the following order: (1) a small loop of intestine 

 clamped off or ligatured suddenly, avoiding large arteries and 

 veins; (2) a portion of one lobe of the liver, using a large clamp 

 suddenly applied; (3) one pole of the spleen, (4) one kidney. 

 After "shock" the same order was followed. So far, in most of 

 our work the same animal has served for "before" and "after" 

 determinations. This perhaps introduces doubt as to the condi- 

 tion of abdominal organs if shock were produced before opening 

 the abdomen. We shall extend the experiments with variations 

 as soon as a large series of "before" percentages is available for 

 averaging. 



Results. — Leg: three experiments; less percentage of blood 

 after shock in all. 



Thyroid: two experiments; less after shock in both. 



Intestine: six experiments; less after shock in four cases ; more 

 in two. These two were early experiments, in which we were not 

 so careful to exclude large vessels. 



Liver: seven experiments; less after shock in six cases; more 

 in one. The one case is doubtful, as 52 per cent, of blood was 

 indicated, probably due to an error in weighing or other manipula- 

 tion. 



Spleen: eight experiments; less after shock in seven; equal in 

 one. 



Kidney: nine experiments; less after shock in eight; more in 

 one. 



The differences are often extreme. In one case the kidney 

 excised before shock contained six times as much blood as its com- 

 panion excised after shock. 



