i8o 



Scientific Proceedings (39). 



1 1 5 (525) 



Inflammation in tissues separated from connection with the 

 central nervous system. 



By W. G. MACOALLUM, M.D. 



[From the Department of Pathology, College of Physicians and Sur- 

 geons Columbia University.] 

 An attempt was made to study the cause of inflammation in 

 tissues separated from connection with the central nervous system 

 as compared with that in normal tissues. The mere section of 

 the nerves going to an organ or limb is insufficient, for nerve fibrils 

 accompany the blood vessels. To overcome this an extremity was 

 amputated completely and replaced by anastomosing the blood 

 vessels and bringing together muscles and skin. Inflammatory 

 irritants applied symmetrically to the intact, and to the amputated 

 limb of the dog resulted in the production of quite the same 

 phenomena of inflammation on both sides. The reddening 

 due to the dilatation of the blood vessels was perhaps slightly 

 more intense on the amputated side than in the intact limb. 

 Evidently, the control of the central nervous system is not at all 

 necessary for the development of inflammatory changes. 



