Scientific Proceedings. 



29 



evidence is based on observations of the amount of sugar in the 

 blood, this being assumed to be increased whenever the urine 

 strongly reduces. We have accordingly undertaken a reinvesti- 

 gation of the foregoing evidence but have examined the reducing 

 power of the blood instead of that of the urine. 



Of certain of our results, viz., those relating to the influence of 

 nicotin and of lowered blood pressure on the blood sugar, we have 

 already made preliminary communication. 1, 2 



In the present communication are reported the results which 

 we have so far obtained on the changes in the amount of sugar 

 (reducing substance) of the blood resulting from stimulation of the 

 spinal cord at various levels, and from stimulation of the splanchnic 

 nerves. The sugar analyses were performed by the method of 

 Waymouth Reid. 3 



The following table gives the averages of the results so far 

 obtained : 



Nature of Experiment. 



No. of Exps. 



Blood Sugar in 

 gm. Per cent. 

 Before Stimu- 

 lating. No. of 

 Analyses Inclu- 

 ded in Averages. 



Blood Sugar in 

 gm. Per cent. 

 After Stimu- 

 lating. No. of 

 Analyses Inclu- 

 ded in Averages. 



Stimulation of peripheral end of one 

 splanchnic nerve, the opposite splanch- 



Stimulation of cut spinal cord below the 



6 

 7 



1 



2 



2 



o.i33 (9) 

 0.163 (8) 



0.140 (2) 

 0.189 (3) 



0.140 (2) 



o-H5 (9) 

 0.160 (12) 



0.236 (2) 

 0.276 (4) 



0.157 (6) 



Stimulation of lower cervical region of 

 spinal cord. 





C. With oxygen freely administered by 



It will be seen that no hyperglycemia is produced by stimula- 

 tion of the splanchnic nerves, or of the spinal cord below the cer- 

 vical region. In the cervical region, on the other hand, stimu- 

 lation produces hyperglycemia except when oxygen is very freely 



1 Macleod and Dolley : Proceedings of the Physiological Society, Journal of 

 Physiology, 1905, xxxii, p. lxiii. 



2 Macleod and Briggs : Proceedings of the Toronto meeting of the British Medical 

 Association, British Medical Journal, Dec. 22, 1906. 



3 Reid: Journal of Physiology, 1896, xx, p. 316. 



* Hirsch : Ueber Kiinstliche Atmung durch Ventilation der Trachea. Dissertation, 

 Giessen (1905) ; ref., Biophysikalisches Centralblatt, 1905. 



