Scientific Proceedings. 



49 



very interesting to ascertain to what extent lecithin is concerned 

 in venom lysis caused by fresh serum. 



35 (178) 



Effects of experimental injuries of the pancreas. 



By ISAAC LEVIN. 



[From the Department of Pathology of Columbia University, at 

 the College of Physicians and Surge ons.~\ 



A review of the experimental work done so far shows clearly 

 that injuries of the pancreas produce different effects on the or- 

 ganism than the complete removal of the organ. After the latter 

 operation the animal succumbs with the symptoms of subacute 

 diabetes, but a comparatively slight injury to the organ may kill it 

 within twenty-four hours, producing an entirely different symptom 

 complex. 



It seems very difficult to form a correct idea of the etiological 

 relation between a certain injury to the pancreas and the disease 

 process that so rapidly kills the animal, because in all the experi- 

 mental work thus far reported, an injury which results fatally in a 

 certain number of animals, produces no effects on others. 



Doberauer reported (in Centralbl. fur Chir. y Nr. 28, 1906) a 

 series of twenty-one experiments on dogs. In each case he doubly 

 ligated and severed the pancreas with identical results in all the 

 experiments, viz., the development of fat necrosis, sub-serous peri- 

 toneal hemorrhages and free hemorrhagic fluid in the peritoneum. 

 The animals were either dead or moribund within twenty-four hours. 

 The author ascribes the fatal results in his experiments to a com- 

 bination of stasis of secretion, some abnormality in the circulation 

 and a lesion of the parenchyma of the pancreas. The experiments 

 of Doberauer differ from all previous investigations in the fact that 

 he obtained the same results in every experiment. It seemed 

 advisable to repeat his experiments, because, if found correct, they 

 could subsequently be varied so as to afford a clearer insight into 

 the etiological moment of the injury which produced the acute fatal 

 disease of the animal. 



The operation of Doberauer was first repeated in exactly the 



