50 Society for Experimental Biology and Medicine. 



same manner on six dogs. Of these animals only one died in twenty- 

 four hours. The autopsy showed congestion of the pancreas near 

 the ligatures (otherwise the organ was macroscopically normal), 

 sero-fibrous peritonitis and no fat necrosis. The other animals 

 remained healthy, and when subsequently killed, showed noth- 

 ing abnormal at autopsy. Thus the results in this first series of 

 experiments did not seem to coincide with those of Doberauer. 

 It remained to be seen whether better results could not be obtained 

 by varying the experiments to some extent. A priori it seems 

 certain that the deleterious effect of the injured pancreas on the 

 organism is due to a change either in the secretion of the organ or 

 in its circulation or in the parenchyma, or in a combination of the 

 three. In the first series of experiments the result was mostly a 

 stasis of secretion. 



In the second series undertaken on four dogs, a part of 

 the pancreas about an inch long was crushed with an artery for- 

 ceps in the middle of the gland and every bleeding vessel ligated 

 separately. In this way some of the parenchyma of the organ was 

 injured and instead of producing a stasis of the secretion, it was 

 given a free exit in the peritoneum. All four animals remained 

 normal. 



In the third series of experiments the pancreas was either doubly 

 ligated or part of it crushed and, besides, the most important veins 

 leading from the pancreas were ligated. In this operation a hemo- 

 stasis was added to the results produced in the previous experi- 

 ments. The operation was performed on six dogs. Three dogs 

 died in from twenty-four to forty-eight hours. The autopsy 

 showed acute pancreatitis with fat necrosis. The other three dogs 

 remained apparently healthy, but when killed subsequently showed 

 at autopsy a condition of interstitial pancreatitis. These investiga- 

 tions are not yet near completion, but so far as can be judged from 

 the material on hand, those injuries produce the gravest effect on 

 the organism which cause the most serious interference with the 

 circulation of the pancreas. To produce a fatal disease it does not 

 suffice to interfere partly with the free secretion of the pancreatic 

 juice into the intestines as in the first series of experiments, or to 

 injure some of the parenchyma and at the same time allow the 

 juice to secrete into the peritoneal cavity, as in the second series. 



