54 Society for Experimental Biology and Medicine. 



urine showed marked diminution during the first alcohol period, 

 when the average daily output was 255.3 m g s - as against 336.8 

 mgs. in the control period, which is a diminution of 24.2 per cent. 

 When the same volume of 70 per cent, alcohol was administered, 

 however, the difference was less marked, the daily average being 

 297.8 mgs. of sulphur or 1 1.4 per cent, less than in the control 

 period. 



The inorganic and ethereal sulphates of the urines were likewise 

 determined. The former showed a striking diminution during the 

 alcohol periods. When 50 per cent, alcohol was given the daily 

 average output of inorganic sulphates was 133.4 mgs., while the 

 amount eliminated per day during the control period was 208. 1 

 mgs. — a diminution of 36 per cent. With 70 per cent, alcohol 

 the average amount per day was 69.2 per cent. During the after 

 period, when alcohol was discontinued, the inorganic sulphates 

 rapidly returned to the normal. The amount found in the com- 

 bined urines of the 3d and 4th days was about the same as in the 

 control period. In the subsequent days the sulphates steadily 

 increased in amount until on the 9th and 10th days the output was 

 even slightly greater than in the control period. The ethereal sul- 

 phates in the urine of this dog presented very interesting results. 

 There was considerable fluctuation in the amounts found in the 

 control period. The amount excreted during the first 2 days was 

 69.1 mgs. ; 3d and 4th days — 48.6 mgs. ; 5th and 6th days — 

 104.4 m g s - During the first alcohol period, the variation was 

 much less ; the quantity eliminated was also markedly diminished. 

 The diminution continued all through the second alcohol period, 

 as well as in the after period when alcohol was discontinued. The 

 ratio of the simple sulphates to the ethereal sulphates rose in the 

 alcohol period but was highest in the after period. 



The elimination of phosphoric acid likewise showed consider- 

 able diminution in the alcohol periods. While the average amount 

 of P 2 0 5 excreted during the control period was 801 mgs. per day, 

 in the first alcohol period it was 552 mgs. — a diminution of 40 per 

 cent., which practically continued when 70 per cent, alcohol was 

 given. In the after period a decided tendency to return to the 

 normal was noticed but at the end of the 10 days, the amount 

 excreted was 13-15 per cent, below that of the control period. 



