1 1 8 Society for Experimental Biology and Medicine. 



If then we assume that the centrosomes are pulsating in oppo- 

 site phase, or better, oscillating in the same phase, we will obtain 

 the desired repulsion and at the same time have a configuration 

 like that actually observed. 



The configuration taken by the chromosomes is explicable on 

 the same grounds. Indeed, it is not necessary to assume any 

 independent motion on their part, but simply to consider it an 

 induction phenomenon. The tri- and multi-polar spindles are 

 also better explained on these hydrodynamic grounds than on 

 previous assumptions. 



The foregoing explanation is, of course, pure hypothesis, with 

 no support other than the facts it seeks to explain. There is, how- 

 ever, nothing inherently impossible in it, and it may provoke fresh 

 observation and new ideas. 



83 (226) 



Transfusion experiments in dogs showing" artificially implanted 



tumors. 



By GEORGE W. CRILE and S. P. BEEBE. 



[From the Department of Experimental Pathology Cornell Uni- 

 versity Medical College, New York City.~\ 



Direct transfusion of the whole blood from immune dogs to 

 dogs with actively growing, artificially implanted tumors has been 

 carried out upon a series of six animals. The operative method 

 of this transfusion is the same as has been used by one of us in a 

 large series of experiments previously reported in the proceedings 

 of this society. 1 In the first set of three, sufficient time has elapsed 

 to determine the outcome, and we give below brief data of each 

 experiment in this series. 



I. Dog 116. Planted Jan. 7, 1907. Tumors were first seen 

 on Feb. 20 ; continued to grow slowly. March 20, transfusion 

 experiment — dog was bled 400 c.c. and immediately transfused 

 with 550 c.c. of blood from dog 244, in which implantation had 

 occurred on Jan. 1 8th ; tumors were first noticed on Feb. 6th, and 

 had continued to grow until Feb. 20th, when they began to regress. 

 Regression complete March 7th. Three days after transfusion, 



1 Crile and collaborators : This volume, pp. 6, 6.J., 65 and 67. 



