130 Society for Experimental Biology and Medicine. 



The effects of struggle were then taken up. With struggle, 

 as others have shown, the lymph flow increases sharply in amount 

 for a few minutes. With this the author found a corresponding 

 increase in cell content, an increase marked in " cell concentra- 

 tion " per c.mm. of lymph and in the total number of elements 

 passed. Specimens taken at short intervals showed that the curve 

 of increase in cell concentration was not coincident with that of 

 the lymph flow, but was somewhat retarded, the greatest cell 

 increase often existing in the few c.c. of lymph obtained in the 

 quiet immediately following muscular exertion. That a transient 

 flushing out of cells was not responsible for the main results, was 

 shown by the data from long-continued struggle. The cell 

 content and concentration remained high throughout, even when 

 the rate of lymph flow had lessened to that seen previously during 

 quiet. In an instance in which struggle was prolonged to 35 min. 

 slightly more than twice as much lymph was voided, and over 

 four times as many cells, as in the 35 min. of quiet immediately 

 preceding. Following such prolonged exertion the lymph was 

 for a time poorer in cells than previous to it. 



An additional conclusion reached was that, for a given individual, 

 the lymph glands seem "set" to produce cells at definite rate. 

 This rate has a wide range for reasons unknown. The cell 

 increase with struggle comes from the peripheral lymph system 

 rather than from sedimented cells in the receptaculum chyli, and 

 is probably dependent on another factor besides increased lymph 

 flow (a supposition upheld by later experiments with lymphag- 

 ogues). The facts elicited have a bearing on the "physiological 

 mononucleosis " of the blood observed in man following active 

 exercise, on the disappearance of this following prolonged exer- 

 tion (25 mile run), and the absolute decrease in mononuclears 

 sometimes seen. 



92 (235) 

 A lipolytic form of hemolysis. 

 By HIDEYO NOGUCHI. 



\_From the Rockefeller Institute for Medical Research.] 



The varieties of hemolysis hitherto described imply the direct 

 action of certain chemically-defined bodies, acids, alkalis, glucosides, 



