1 62 Society for Experimental Biology and Medicine. 



We sought first to ascertain whether crude elastose, when in- 

 jected subcutaneously or intraperitoneally, is eliminated in the urine 

 and whether it can be detected there by the heat-precipitation test. 

 When thus introduced in dogs, crude elastose, obtained by pep- 

 tolysis of ligament elastin prepared by Richards and Gies's method, 

 not only promptly appears in the urine, but may be identified in it 

 by the heat-precipitation test. This observation makes it clear 

 that if elastose is formed in bone or in any other tissue by any 

 pathological process, the elastose thus produced may pass into the 

 urine without material alteration of the characteristic property 

 referred to. 



Before proceeding further in this connection, osseoalbumoid 

 (bone elastin ?) will be prepared in sufficient quantity to permit of 

 a determination of the nature of its proteoses and their fate when 

 injected into animals. 



