A Method of Producing Experimental Shock. 3 



16-26 days by feeding a mixture consisting of whole soy bean 

 flour, milk, yeast, paper pulp, and inorganic salts, 1 have not been 

 encountered during a period of 75 days in which 10 gm. of raw 

 tomatoes were added daily to the diet. If on the appearance of 

 the clinical scorbutic manifestations attributable to the scurvy- 

 producing diet, 10 gm. of raw tomatoes are added as a daily 

 supplement, the symptoms will subside and the animals will be 

 restored to health. 



Tomatoes dried in a blast of air either for 14-24 hours at 55- 

 6o° C. or for 36-44 hours at 35-40 0 C. retain some of their anti- 

 scorbutic property. This statement is based on the fact that 

 young guinea pigs receiving, a daily addition of 1 gm. of either of 

 such dried products have grown and continued in apparently per- 

 fect health for a period three times as long as that within which 

 the usual scorbutic symptoms appear. 



Further experiments are being conducted upon this subject. 



3 (1378) 



A method of producing experimental shock. 



By T. S. Githens, I. S. Kleiner, A. L. Meyer and S. J. Meltzer 



[From the Department of Physiology and Pharmacology of the Rocke- 

 feller Institute for Medical Research.] 



In the numerous investigations on experimental shock there 

 is no uniformity as to the method of inducing it. Some authors 

 simply say "the animal was reduced to shock," without stating 

 by what method it was induced or how long it took to induce it. 

 Others claim that they have produced profound shock by con- 

 tinuous stimulation of sensory nerves, while other writers are 

 quite positive that it is impossible to induce shock by this method. 

 The method par excellence of producing shock seems to be the 

 exposure of the abdominal viscera. Here again opinions differ. 

 For instance, Erlanger and his coworkers say that in order to re- 

 duce blood pressure to 50 mm. mercury, an exposure and manipu- 



1 B. Cohen, Proc. Soc. Exp. Biol, and Med., 1918, XV, 102; M. H. Givens 

 and B. Cohen, ibid., 1918, XV, 126; Cohen, B., and Mendel, L. B., J. Biol. Chem., 

 1918, XXV, 425; M. H. Givens and B. Cohen, J. Biol. Chem., 1918, XXXVI, 127. 



