Metabolism of Acids in the Monkey. 



5 



ately again when the animal is left for some time without ether and 

 without squeezing of the gut. In one dog with original blood 

 pressure of 160, the blood pressure which fell to 68 mm. rose after 

 three hours to 120 mm. It is different, however, with the sensory 

 shock. In not a single instance did the pain sense return at any 

 time. This holds good even for cases in which the lid reflex was 

 prompt. 



The subject will require a great deal of detailed study. But 

 we thought of putting our experiments on record on account of 

 the value it may have for experimental shock and especially on 

 account of its possible practical importance in human surgery. 

 In abdominal surgery no care is taken to avoid compressing of 

 the gut; on the contrary, it is often employed to achieve a definite 

 end. On the other hand, traction on the mesentery is carefully 

 avoided. In our experience traction on the mesentery rather 

 favors some rise of blood pressure. 



4 (1379) 



Metabolism of p-hydroxybenzoic acid and p-hydroxyphenyl- 

 acetic acid in the monkey. 



By Carl P. Sherwin. 



[From the Chemical Laboratory of Fordham University Medical 



School.] 



^-hydroxy benzoic acid was fed to a monkey in one, two and 

 three gram doses, the urine was collected for 36 hours following 

 each dose, evaporated and extracted. The urine was found in 

 every case to contain only the uncombined acid. This agrees 

 with the findings of other investigators who have fed this acid to 

 several of the lower animals. In each case from 50-60 per cent, 

 of the acid was recovered from the urine. 



After feeding ^-hydroxyphenylacetic acid in one or two gram 

 doses, approximately 60 per cent, of this acid was recovered from 

 the urine of the monkey. Some of this acid existed in the free 

 state, while a portion of it was excreted in the urine in combina- 

 tion with glycocoll as ^-hydroxy phenaceturic acid, ^-hydroxy- 



