Intrapulmonary Irrigation. 



55 



virus produced typical experimental poliomyelitis in the monkey 

 which has been exposed to large doses of X-rays (6 Holzknecht 

 units daily for six or seven days), whereas in the non-rayed control 

 no symptoms were observed. The doses of X-rays were sufficient 

 to reduce greatly the number of circulating lymphocytes in the 

 blood of the monkeys. In another experiment 0.75 c.c. of the 

 filtrate produced typical experimental poliomyelitis in the X-rayed 

 monkey, whereas 1.0 c.c. produced no symptoms in the control. 



In an attempt to diminish an active immunity a monkey which 

 had passed through an attack of experimental poliomyelitis and 

 recovered with residual paralysis was exposed to large doses of 

 X-ray so that the circulating lymphocytes were decreased from 

 27,000 per cu. mm. to about 2,500. Two separate intracerebral 

 injections of active virus failed to produce any further symptoms 

 or paralyses in this monkey. 



35 (1410) 



Intrapulmonary irrigation. 



By M. C. Winternitz and G. H. Smith (by invitation). 



[Department of Pathology, Yale School of Medicine, New Haven, 



Conn.] 



In view of the limitations of the intravascular mode of therapy 

 of respiratory conditions, as exemplified in pneumonia, a series of 

 experiments has been conducted looking into the possibility of an 

 intratracheal or intrapulmonary therapy for such conditions. 



The data thus far secured demonstrates the fact, fundamental 

 to any such therapeutic procedure, that the lung is much less 

 susceptible to the introduction of fluid than has been generally 

 assumed. 



Normal dogs have been used throughout the work and all 

 perfusions or irrigations have been made with normal salt solution. 

 The fluid was introduced by the usual method of insufflation. 



Repeated experiments have shown that the lungs can be en- 

 tirely flooded with salt solution and the process of irrigation con- 

 tinued for at least two hours with the introduction of 30,000 c.c. 

 of fluid without causing any evident harmful signs in bodily well- 



