82 



Scientific Proceedings (97). 



physis in these larvae is always present, though greatly under- 

 developed — ample proof apparently of the need of coassociation 

 with the epithelial portion of the gland. Most emphatic is the 

 effect produced on the adrenal, whose cortical or interrenal sub- 

 stance is greatly decreased. This discovery was greatly facilitated 

 by the employment of those methods which fix and stain the 

 lipoids of the cortical tissue. These changes in the adrenal tissue 

 do not occur in thyroidectomized larvae and are consequently not 

 to be referred to the thyroid reduction which is coincident with 

 them. 



47 (1422) 



On the occurrence of degenerative changes in the liver in animals 

 intoxicated by mercuric chloride and by uranium nitrate. 1 



By William deB. MacNider. 



[From the Laboratory of Pharmacology University of North 

 Carolina, Chapel Hill.] 



The following observations are based on the study of fifty- two 

 intoxications by mercuric chloride and eighty-four intoxications 

 by uranium nitrate. Dogs were employed for the experiments. 

 In the animals intoxicated by mercuric chloride, the poison was 

 administered by stomach tube in the dose of 15 mgs. per kilogram. 

 In the uranium intoxications, the poison was given subcutaneously 

 in doses varying from 4 to 6.4 mgs. per kilogram. 



The experiments were terminated at different periods during 

 the intoxication without employing an anesthetic. Such a 

 termination has eliminated the acute degenerative changes in the 

 liver which may develop very rapidly from the use of such an 

 agent. The changes in the liver in both types of intoxications 

 have shown great variation in their severity and the rapidity with 

 which they occur. 



Mercuric Chloride Intoxications 

 All of the animals in this group, with eight exceptions, de- 

 veloped a severe gastroenteritis. The stools were frequent and 



1 Aided by a grant from The Rockefeller Institute for Medical Research. 



