Chinosol and Salt. 



107 



brings the chinosol-salt solution into contact with the wound, and 

 the external dressings, in order to prevent abstraction of the solu- 

 tion into the latter. 



Animal experimentation was done to prove the value of chino- 

 sol as a first-aid disinfectant. In the animal experiments the 

 wounds were constructed as pockets between the superficial and 

 deep layers of the superficial fascia in a dog's back. These pock- 

 ets, when made blood-free, would absorb the solution very freely 

 no matter what was the strength of the salt, but when the tissues 

 were infiltrated with blood the absorption of the solution would be 

 slower or sometimes there would be none at all. 



The instances in which primary union followed the disinfection 

 of a scientifically infected wound, where the infection preceded 

 the disinfection, were not frequent. One case which gave en- 

 couragement to the work, was that of a dog infected with staphy- 

 lococcus aureus, having used as much of a 24-hour culture as could 

 be taken up by a piece of gauze about 1 by iJ4 inches square, 

 crumpled up, which was left in the wound for thirty minutes, the 

 wound then being disinfected with a solution of chinosol grains vi 

 to the ounce and 0.6 per cent sodium chloride, in which primary 

 union took place in the disinfected wound, while from the control 

 wound on the opposite side an extensive cellulitis developed, which 

 resulted in a large area of superficial necrosis with ulceration ex- 

 tending from near the back bone forward to the anterior median 

 line. 



In a recent series of experiments performed on 12 dogs, in which 

 the lymphatics leading from wound pockets between the layers of 

 the superficial fascia, uncontaminated with blood, were first infil- 

 trated with the disinfectant solution before infecting the wounds 

 with as much of a virulent 24-hour culture of Staphylococcus aureus 

 as could be absorbed on a piece of gauze about half an inch square, 

 crumpled up and deposited in the bottom of the pocket for 30 

 minutes, and the disinfectant solution was applied to the wounds 

 again following the infection, the wounds having been finally 

 sutured primarily, these same wounds in seven of the animals 

 united by primary union, while the controls all suppurated. The 

 strengths of chinosol used in this series of animals were grains iv 

 and vi to the ounce, and 2 per cent., and of sodium chloride, 0.85 

 and 0.6 per cent. 



